Chemotherapy-induced nausea and vomiting (CINV) stands as one of the most debilitating and feared side effects of cancer treatment, significantly eroding a patient’s quality of life and adherence to vital therapeutic regimens. Despite advancements in conventional antiemetic drugs, a substantial number of cancer patients continue to experience breakthrough or refractory CINV, highlighting an unmet medical need. The mechanisms driving CINV are complex,
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